Immobilisation stress induced analgesia in diabetic rats.
نویسندگان
چکیده
Stress is known to produce analgesia. The pain threshold is altered in diabetes. We studied the effect of 1 hr of immobilisation stress on pain threshold in male Wistar rats. The same effect was tested in streptozotocin induced diabetic rats. The pain threshold of tail flick, vocalisation and vocalisation after discharge increased in the control group after the stress procedure. Significant analgesia was also obtained in diabetic rats, for flick and after discharge pain threshold. However the vocalisation threshold was not altered, probably due to the antagonistic action of glucose on opiate receptor at the level of brain stem.
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ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 41 3 شماره
صفحات -
تاریخ انتشار 1997